3 edition of Forkhead transcription factors found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Kenneth Maiese.|
|Series||Advances in experimental medicine and biology -- v. 665, Advances in experimental medicine and biology -- v. 665.|
|Contributions||Maiese, Kenneth, 1958-|
|LC Classifications||QP552.T68 F67 2009|
|The Physical Object|
|LC Control Number||2009034453|
This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Forkhead Transcription Factors Subject Areas on Research A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development Seungwoon Seo, Hideo Fujita, Atsushi Nakano, Myengmo Kang, Antonio Duarte, Tsutomu Kume *Cited by: The members of the Forkhead box (FOX) family of transcription factors share a conserved winged-helix DNA-binding domain (DBD) known as the Forkhead domain [1,2].This domain consists of approximately amino acids and folds into three major α-helices (H1-H3), a short twisted three-stranded antiparallel β-sheet (comprising three β strands S1–S3) and two wing-like loops (W1 and W2), and Cited by: 3.
Forkhead transcription factors. Functions of FoxO. Cardiovascular forkhead effects. Metabolic forkhead effects. Histone acetylation and deacetylation. Sirtuin deacetylases. Sirtuin regulation. Antiinflammatory, cardiovascular, and myocyte. sirtuin effects. Sirtuin effects on metabolism. Sirtuins and cell longevity. Forkhead deregulation and. The Forkhead Box (Fox) proteins are an extensive family of transcription factors that share homology in the Winged Helix/Forkhead DNA binding domain (25–27). Fox proteins Foxa2, Foxj1, Foxf1, and Foxp play important roles in regulating transcription of genes involved in branching lung morphogenesis and vasculogenesis during lung development.
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Forkhead transcription factors are classified based on a conserved winged helix/forkhead DNA-binding domain consisting of three β-sheets, three α-helices, and two loops forming the “wings”. FOXL2, is present in the pituitary, ovary, and developing eye and is the forkhead factor that has been studied most extensively in reproduction.
Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body.
Leading international authorities provide theirBrand: Springer-Verlag New York. Forkhead FOXO Transcription Factors in Development and Disease, Volumethe latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease.
Forkhead FOXO Transcription Factors in Development and Disease, Volumethe latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease.
Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights. Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body.
Leading international authorities provide their knowledge and insights to offer a novel Format: Hardcover. Forkhead FOXO Transcription Factors in Development and Disease.
Edited by Saghi Ghaffari. VolumeShow all chapter previews Show all chapter previews. Receive an update when the latest chapters in this book series are published. Sign in to set up alerts. select article Series Page Regulation of FOXO Factors in Mammalian Cells.
https. Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily.
In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and by: Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body.
The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and : Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng.
Forkhead transcription factors, and the vital role they play in systems throughout the body, are presented in this reference.
Leading experts highlight forkhead genes and proteins that may aid the Read more. We have previously shown that hepatitis C virus (HCV) infection modulates the expression of forkhead box transcription factors, including FoxO1 and FoxA2, which play key roles in gluconeogenesis and β-oxidation of fatty acid, respectively.
The aim of the present study was to determine the role of forkhead box transcription factors in Cited by: Forkhead Box Protein L2 (FOXL2) is an important transcription factor, and member of the Forkhead Box (FOX) protein family present in a huge range of organisms.
This family exhibits a highly conserved structure of alpha helices and a highly conserved amino acid DNA binding domain. Abstract Forkhead transcription factors represent an important family of proteins, for which more than family members have been identified so far, 26 of which can be found in humans.
In many type I endometrial cancers, the PTEN gene is inactivated, which ultimately leads to constitutively active Akt and the inhibition of Forkhead box O1 (FOXO1), a member of the FOXO subfamily of Forkhead/winged helix family of transcription by: Read "Forkhead FOXO Transcription Factors in Development and Disease" by Saghi Ghaffari available from Rakuten Kobo.
Forkhead FOXO Transcription Factors in Development and Disease*, Volume **,* the latest release in the Current Topics Brand: Elsevier Science. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the.
The forkhead (Fox) gene family comprises a diverse group of ‘winged-helix’ transcription factors that play important roles in development, metabolism, cancer and aging.
Recently, several forkhead genes have been demonstrated to play critical roles in lymphocyte development and effector function, including Foxp3 in the development of regulatory T cells, Foxj1 and Foxo3a in the regulation Cited by: Those who downloaded this book also downloaded the following books: Comments.
Forkhead transcription factors all share a conserved DNA-binding domain (DBD) of amino acids that folds into a winged helix structure termed the forkhead box.
Two major compliments: (1) through publishing the book chapter, we enhanced disseminating the knowledge of FoxO transcription factors regulating autophagy in health and diseases, and (2) through presenting the cutting-edge research at the scientific conference, we brought to the community the up-to-date understanding of FoxO1 in adipose biology.
Abstract. The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF, which is a downstream target of two Akt .Forkhead transcription factors were first discovered more than 10 years ago in Drosophila and are characterized by a shared amino acid DNA-binding motif, termed the “winged helix” or “forkhead” domain.
Conserved forkhead domains have been identified in eukaryotic organisms from yeast to humans. The human genome.In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right.